Stable-vitamin-containing therapeutic preparation



Patented Apr. 2, 1940 umrao STATES PATENT OFFICE STABLE-VITAMIN-CONTAINING THERAPEU- TIC PREPARATION Ferdinand W. Nitardy, Brooklyn, N. Y., assignor to E. B. Squibb & Sons, New York, N. Y.. a corporation of New York No Drawing. Application November 7, 1936, Serial No. 109,758

4 Claims. (CL 167-81) This invention relates to vitaminic therapeutic occluded air), whereupon (a) the mixture of and alimentary preparations, and has for its obgr nu a Preferably While S l under Vacuum ject the provision of methods and means whereby (to facilitate penetration of the solution), is such preparations may be stabilized against loss treated with a vitaminic substance, such as the 5 of potency, liver oil of the halibut, swordfish, tuna, or salmon, 5

On account of their lability in the presence of wheat-germ oil, or a concentrate thereof, or air, it was proposed to protect vitaminic subirradiated ergosterol or cholesterol, or mixtures stances--including the liver oils of such fishes as of two or more of these, preferably dissolved in a the halibut, swordfish, tuna, and salmon, conmelted fat, and mixed with a small amount (0.5%

centrates thereof, the germ oils of such cereals to 2.0% of the fat used) of an alkaline substance 10 as wheat, and irradiated ergosterol and cholessuch as magnesium oxide, magnesium hydroxide, terolby incorporating them into fatty materials calcium oxide, calcium hydroxide, or sodium car- (which term, as used herein, embraces fats and bonate; or (b) the mixture of granulations, prefoils and edible higher alcohols, especially sterols, erably while still under vacuum, may have a solupreferably solid at room temperatureand fusible tion of one or more of these vitaminic substances 16 at body temperature, among them cocoa butter (dissolved in a volatile solvent, such as ether, and propylene glycol stearate); but even when which is subsequently evaporated 01f) poured over thus protected (i. e., by envelopment and dilution it and, together with one of the above-named of the vitaminic substance),the preparations conalkaline powders, the ingredients may be well 20 tinued to lose potency. It was then found that mixed in order to distribute the vitaminic sub- 20 the acids produced by the rancidification of the stance and the powder uniformly over the granfatty material accelerated the deterioration of the ules. The finished granulation may be packaged vitamins and tended to negative the protective and/or consumed, or tablets may be prepared action of the fatty material. therefrom in accordance with standard pharma- 5 In the practice of this invention, therapeutic ceutical procedures.

and alimentary preparations comprising fatty materials into which vitaminic substances have Example 2 been incorporated are stabilized by mixing an alkaline substance therewith. Among the alka- 0 line substances suitable for the purposes of this invention are the oxides and hydroxides, and the carbonates and other alkaline salts, of the alkaline-earth and alakli metals and of ammonia and its derivatives.

Preparations of the invention may be compounded by any of the known processes; and appropriate auiuhary dletary f medlcnies of an alkaline substance has been added, the sol- Sorbent earners g(.:a1cmm salts) exclpients' vent, if volatile, being permitted to evaporate sweetening and fiavonng agents antioxldants while the mixture cools. Pellets of about 05 g 40 and other ingredients may of course be included. each may be formed (as by extrusion) from 40 Example 1 mass, or the mass may be granulated and filled into ordinary gelatin capsules.

About 0.75 g. of irradiated ergosterol, or an equivalent. amount of irradiated cholesterol, is dissolved in 2.5 kg. of melted cocoa butter to which a small amount (0.5% to 2.0% of the cocoa butter) of one of the alkaline substances enumerated in Example 1 has been added; or the irradiated sterol may be dissolved in corn oil or other suitable solvent and the solution stirred into the 5 melted cocoa butter to which a similar amount Dicalcium phosphate grams 640 Calcium gluconate do 960 x mple 3 Powdered sugar do 400 Grams Sodium carbonate 25 Solid-fat solution of fish-liver oil 20 Water cc 420 W eat g r 980 The dicalcium phosphate and the lciu glu- One part of a mixture of halibut and tuna liver conate are separately granulated with the aid of oils, together with 0.3% of hydroquinone, is dis- 50 the sugar and water, the sodium carbonate being solved in 9 parts of cocoa butter; a small amount dissolved in the portion of the water used to (0.5 to 2.0% of the cocoa butter) o a s u granulate the calcium gluconate. The granulaoxide is added; and the mixture is chilled and tions are then dried, milled to a uniform size, granulated. These granules are thoroughly 5 mixed, and the mixture evacuated (to remove mixed with the wheat germ to form a relatively stable food product rich in vitamins A, B, D, and G It is to be understood that the foregoing examples are merely illustrative and by no means 1imi tative of the invention, which may be variously otherwise embodied--as with respect to the specific alkaline substances, fatty materials, and other ingredients, and procedures-within the scope of the appended claims.

I claim:

1. A stable protected-vitamin-containing therapeutic or alimentary preparation essentially comprising an intimate admixture of a solid solution of a fat-soluble vitaminic substance in a solid fatty material with an alkaline substance.

2. A stable protected-vitamin-containing ther- 'apeutic or alimentary preparation essentially comprising an intimate admixture of a solid solution of a vitaminic fish-liver oil in a solid fatty material with an alkaline substance.

3. A stable protected-vitamin-containing therapeutic or alimentary preparation essentially comprising an intimate admixture of a solid solution of a vitaminic fish-liver oil in cocoa butter with magnesium oxide.

4. A stable protected-vitamin-containing therapeutic or alimentary preparation essentially comprising an intimate admixture of a solid solution of irradiated ergosterol in cocoa butter with an alkaline substance.

FERDINAND W. NI'IARDY. 

